Antiviral efficacy testing and pk analysis in non-human primates

Prophylaxis and Therapy (delayed treatment) (Deep) sequencing, mutation-specific PCR Any route of drug administration possible (IV, oral, nebulizer, etc.) Read outs include: clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by...

Antiviral efficacy and pharmaco kinetics testing in ferrets

Prophylaxis and Therapy (delayed treatment) (Deep) sequencing, mutation-specific PCR Any route of drug administration possible (IV, oral, nebulizer, etc.) Read outs include: clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by...

Vaccine immunogenicity- and efficacy testing in ferrets  

Humoral immune responses (ELISA, Virus Neutralization, Plaque Reduction, Haemagglutination Inhibition, etc. ) Cell-mediated immune responses; Prime-boost strategies; Production of hyper immune serum; Longevity of protection; Dose-finding, Dose-optimization; Clinical...

Animal model development: novel approaches

Immunocompromised ferret model In vivo imaging Rapid development of animal models for emerging viruses PLoS Pathog. 2013 May;9(5):e1003343.   Prolonged influenza virus shedding and emergence of antiviral resistance in immunocompromised patients and ferrets. van der...

Animal model development: other species / other viruses, etc.

Ferrets Rabbits Cats Non-human primates Vaccine. 2013 Jun 28. pii: S0264-410X(13)00880-3. Low pathogenic avian influenza A(H7N9) virus causes high mortality in ferrets upon intratracheal challenge: A model to study intervention strategies. Kreijtz JH, Kroeze EV,...

Vaccine immunogenicity- and efficacy testing in non-human primates

Active- and passive immunization strategies Read outs include: antibody responses, cell-mediated immune responses, clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by quantitative PCR and virus titration), gross pathology,...