Animal model development: other species / other viruses, etc.

Ferrets Rabbits Cats Non-human primates   Published online: 18 Nov 2021  Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses npj Vaccines (2021) 6:135 ; https://doi.org/10.1038/s41541-021-00395-4. Christopher L. D. McMillan,...

Animal model development: novel approaches

Immunocompromised ferret model In vivo imaging Rapid development of animal models for emerging viruses Viruses 2018 January; 1(10): doi10.3390/v10010018  Transmission of Human Respiratory Syncytial Virus in the Immunocompromised Ferret Model.  Leon de Waal, Saskia L....

Vaccine immunogenicity- and efficacy testing in ferrets  

.Humoral immune responses (ELISA, Virus Neutralization, Plaque Reduction, Haemagglutination Inhibition, etc. ) Cell-mediated immune responses; Prime-boost strategies; Production of hyper immune serum; Longevity of protection; Dose-finding, Dose-optimization; Clinical...

Antiviral efficacy and pharmaco kinetics testing in ferrets

Prophylaxis and Therapy (delayed treatment) (Deep) sequencing, mutation-specific PCR Any route of drug administration possible (IV, oral, nebulizer, etc.) Read outs include: clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by...

Antiviral efficacy testing and pk analysis in non-human primates

Prophylaxis and Therapy (delayed treatment) (Deep) sequencing, mutation-specific PCR Any route of drug administration possible (IV, oral, nebulizer, etc.) Read outs include: clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by...

Vaccine immunogenicity- and efficacy testing in non-human primates

Active- and passive immunization strategies Read outs include: antibody responses, cell-mediated immune responses, clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by quantitative PCR and virus titration), gross pathology,...