MEET THE SCIENTIST BEHIND THE SCIENCE

 

 

An interview with lead author Penelope Koraka, sharing her latest insights on Rabies, recently published in Frontiers in Microbiology.

OUR ASSAYS

You can rely on Viroclinics Biosciences to outsource your research questions, including efficacy, safety, passive immunization, immunogenicity, pharmaco kinetics, pathogenicity, antiviral therapy, antiviral prophylaxis, drug delivery, resistance mutants, etc. With more than 4500 sqm clinical laboratories , equipped with the latest technologies, we have the in-house capabilities to perform several read outs: virus titres, virus copies, plaques, PCR, DNA sequencing, amino acid sequencing, antibody titres, CMI, genomics, clinical signs, etc.

Viroclinics Biosciences has the availability of a wide range of diagnostics platforms and assays. Our specialized and dedicated team of scientists are available to support our clients with R&D, pre-clinical and clinical development programs. The overview below lists our main assay platforms.

Click ‘+’ for viral targets

Cell Culture Chemiluminescence immuno assay

IgG B19 virus
IgG Epstein Barr virus NA
IgG Epstein Barr virus VCA
IgG Herpes Simplex virus type 1 en 2
IgG Herpes Simplex virus type 2
IgM B19 virus
IgM Epstein Barr virus VCA
IgM Herpes Simplex virus
IgG Epstein Barr virus EA

Chemiluminiscence Microparticle Immuno Assay

anti HBc
anti HBe
anti HBs
anti Hepatitis C virus
HBeAg
HBsAg
HBsAg kwant.
HIV-Combo (aHIV en P24 Ag)
HTLV 1 of 2
IgG Hepatitis A virus
IgM HBc
IgM Hepatitis A virus

 

Confirmation

Interferon Alpha Neutralizing
Antibody
Interferon Beta Neutralizing Antibody

ELISA - Infectious Disease

Dengue Virus IgG
Dengue Virus IgM Capture
Influenza A IgG
Mumps IgG
PCP IgG
Platelia Dengue NS1 Ag
Ross River Virus IgG
Rubella IgG
VZV IgG

Goldmann-Witmer Coefficient

IgG Cytomegalovirus
IgG Epstein Barr virus VCA
IgG Herpes Simplex virus
IgG Measles virus
IgG Varicella Zoster virus
Rubella virus

Hemagglutination Inhibition (HAI) Test

(>60 validations on file):

Chicken, Guinea Pig RBCs
Pandemic Influenza Virus (H5N1) – Horse RBCs
Pandemic Influenza Viruses (H9N2 and H1N1) – Turkey RBCs
Virus Titering (HA)
Seasonal Influenza Viruses (H1N1, H3N2, B) – Turkey

Immunochromatography

Flu A (quick test)
Flu B (quick test)
RSV  (quick test)

Enzymimmunoassay

(inc. quantitative and qualitative):

Adenovirus
Astrovirus
Rotavirus
Dengue NS1
HIV p24-antigeen
Ig Hepatitis D virus
IgA Adenovirus
IgA Coxackie virus
IgA Echo virus
IgA Entero virus
IgA Influenza A virus
IgA Influenza B virus
IgA Parainfuenza type 1,2 and 3
IgG Measles (v)
IgG Mycoplasma Pneu
IgG Parainfuenza type 1
IgG Parainfuenza type 2
IgG Rabies virus
IgG Respiratory Syncytial virus
IgG Ross River virus
IgG Rubella virus
IgG Sandfly Fever virus
IgG Tick Born Encephalitis virus
IgG Varicella Zoster virus
IgG West Nile virus screen
IgM Barmah forest virus
IgA Respiratory Syncytial virus
IgG Adenovirus
IgG Barmah forest virus
IgG Bof virus
IgG Coxackie virus
IgG Cytomegalovirus
IgG Cytomegalovirus Aviditeit
IgG Dengue virus
IgG Echo virus
IgG Entero virus
IgG Epstein Barr virus EA
IgG Epstein Barr virus NA
IgG Epstein Barr virus VCA
IgG Hanta virus
IgG Hepatitis E virus
IgG Human Herpes Virus type 6
IgG Influenza A virus
IgG Influenza B virus
IgM Coxackie virus
IgM Cytomegalovirus
IgM Dengue virus
IgM Echo virus
IgM Entero virus
IgM Epstein Barr virus VCA
IgM Hanta virus
IgM Hepatitis E virus
IgM Measles (v)
IgM Mycoplasma Pneu
IgM Ross River virus
IgM Rubella virus
IgM Sandfly Fever virus
IgM Tick Born Encephalitis virus
IgM Varicella Zoster virus
IgM West Nile virus screen
IgG1 total

Immunofluorescence

Adenovirus
Adenovirus
Adenovirus 40
Adenovirus 41
Bofvirus
Corona 229E virus
Corona OC43 virus
Cytomegalovirus
Herpes Simplex virus type 1
Herpes Simplex virus type 1  en 2
Herpes Simplex virus type 2
HMPV
HMPV
IgA Puumala virus
IgG Puumala virus
IgG Rickettsia Conorii virus
IgG Rickettsia Prowazekii virus
IgG Rickettsia Rickettsii virus
IgG Rickettsia Tsutsug. virus
IgG Rickettsia Typhi virus
IgG Rt Valley Fever virus
IgG Rubella virus
IgG Saaremaa
IgG Saint Louis Encephalitis virus
IgG SARS corona virus
IgG Seoul virus
IgG Sin Nombre virus
IgG Tick Born Encephalitis virus
Influenza type-A
Influenza type-A, B, P, A
Influenza type-B
Measlesvirus
Parainfluenza type 1, 2, 3, 4
Picornavirus
Respiratory Syncytial virus  type A&B
Rubellavirus
Varicella Zoster virus
IgA Epstein Barr virus VCA
IgA Hantaan virus
IgG Calornia encephalitis virus
IgG Chikungunya virus
IgG Crimean Congo Hemorrhagic Fever virus
IgG Dengue virus
IgG Dobrava virus
IgG E.chaffeens.
IgG Eastern Equine Encephalitis virus
IgG Ebola virus
IgG Gele-koorts virus
IgG Hantaan virus
IgG HGE virus
IgG Human Herpes virus type 6
IgG Human Herpes virus type 8
IgG Japanse encephalitis virus
IgG Lassavirus
IgG Lymphocytic Chorio Meningitis(v)
IgG Marburg virus

Immunogenicity Screening

Galiximab Ab – Binding Assay
Tysabri Ab – Binding Assay
Galiximab PK
α-IFN Ab – Binding Assay
KLH Ab
β-IFN Ab – Binding Assay

Influenza Anti-Viral Phenotyping

NA-Star Influenza Neuraminidase Inhibitor Resistance Detection (Oseltamivir)
NA-Star Influenza Neuraminidase Inhibitor Resistance Detection (Zanamivir)

Latex agglutination test

Rotavirus

Line Immuno Assay

Hepatitis C confirmatie
HIV confirmatie type 1 of 2
HTLV confirmatie type 1 of 2

Line Immuno Probe Assay

Hepatitis B virus pol gen
Hepatitis C virus genotypering
Hepatitis B virus surface gen
Human Papilloma virus

Luminex

Total, IgG1, and IgG4 Antibodies to Influenza Hemagglutinin

Micro-immunofluorescence assay

IgG Cytomegalovirus
IgG Epstein Barr virus VCA
IgG Herpes Simplex virus
IgG Rubella virus
IgG Varicella Zoster Virus

Microneutralization Test

Adenovirus
Dengue Virus
Influenza (H1N1, H5N1, H9N2)
Poliovirus
West Nile Virus

Neutralisation

Virusneutralisation test Adenovirus typing
Neutralisation IgG Rabies (FAVN)
Virusneutralisation test Enterovirus typing

Plaque Reduction Neutralization Test (PRNT)

ACAM2000
ChimeriVax-JE
Dengue Virus
DryVax (NYCBOH)
Japanese Encephalitis Virus
La Crosse Encephalitis Virus
LC16m8
Nakayama
Respiratory Syncytial Virus
St. Louis Encephalitis Virus
West Nile Virus
WR (Western Reserve)
Yellow Fever Virus (17D)

Quantitative Culture

Influenza Virus (TCID50)
Rhinovirus (TCID50)

Sequence analysis

Sequence analysis
Cytomegalovirus  UL97
HIV V3 loop
Cytomegalovirus UL54
HIV1 Integrase gen
Entero virus
HIV1 prot gen 1
Hepatitis B virus core gen
HIV1 RT gen 1
Hepatitis B virus RT gen
HIV2 prot gen 1
Hepatitis B virus s gen
HIV2 RT gen 1
Hepatitis B virus totaal
Orthopox virus
Hepatitis C virus
Parechovirus

Virus Isolation

Adenovirus/vector detection, viral culture
Conventional Viral Culture – Multiple cell lines
MDCK / RHMK Shell Vial Culture
Rapid Influenza Culture

Sequencing: Polymerase chain reaction (Inc. quantitative and qualitative)

119E
Human Herpes virus type 6
119V
Human Herpes virus type 8
274Hmex
Human metapneumovirus
274Ymex
Influenza A-H1, H3, H5, H7, H1-N1 mex
292K
influenza type B virus
292R
Japanse encephalitis virus
ADV
JC virus
B19 virus
Lassavirus
BK virus
Lymphocytic Chorio Meningitis virus
Bocavirus
Measles virus
Bofvirus
Mycoplasma pn.
Chikungunya virus
Mycoplasma sp.
Corona 229E virus
Noro virus
Corona OC43  virus
Orthopox virus
coronavirus SARS  virus
Parainfluenza type 1, 2, 3 en 4
Cytomegalovirus
Parapoxvirus
Denguevirus
Parecho virus
Ebola virus
Rabies virus
Enterovirus
Respiratory Syncytial virus type A en B
Epstein Barr virus
Rhinovirus
Yellow Fever
Rubella virus
Hantavirus
Tick Born Encephalitis virus
Hantavirus Puumalavirus
Varicella Zoster virus
HCoV-NL
West Nile virus
Hepatitis B virus cap-ctm
Ad4 / Ad7 PCR
Hepatitis C virus cap-ctm
Ad4-H5 PCR
Hepatitis Delta virus
Dengue PCR
Hepatitis E virus
HCV RNA RT-PCR
Hepatitis G virus
Influenza A/B PCR
Herpesvirus B
Influenza A/B Qualitative and Quantitative PCR
HIV type 1
Influenza A/B/H1/H3/pH1N1 differentiation, PCR
HIV type 2
Influenza H1/H3 differentiation, PCR
Human Herpes virus type 1
Influenza H1N1 Qualitative and Quantitative PCR
Human Herpes virus type 2
JCV Ultrasensitive Quantitative PCR

Full list of viral targets

As a specialized virology CRO we have an established track record based on multiple viruses such as Influenza, RSV, Polio, Rhino/ Entero and many more targets.

Here you can download the full list of viral targets.

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